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Carlota L.

Regenerative therapy for Parkinson's disease

Cellular rejuvenation

Stem cells drive every repair that takes place in the body. For this reason, regenerative therapies have an incredible range of applications [2].

Research suggests that rejuvenation comes from the youthful complex of these repair molecules and their growth factors*.

Potential benefits

Restores cellular function*.

Promotes regeneration*.

Repairs damaged cells or tissues*.

Regulates the immune system*.

Decreases inflammation*.

Licensing and authorization by COFEPRIS, the Mexican FDA

Validated therapeutic protocols

Certified and experienced clinical team

Benefits demonstrated in clinical studies

Cellular products from accredited laboratories

Prestigious medical and scientific advisory board

Therapies to repair

Our cellular therapies are the latest in rejuvenation. We offer the highest standards to meet all regulatory and clinical aspects of the practice*.

Regenerative therapies

Mesenchymal stem cell therapy

Applies to therapy

Our main regenerative therapy harnesses the properties of mesenchymal stem cells.

A personalized therapy with umbilical cord-derived mesenchymal stem cells (UC-MSCs) has the potential to create an optimal internal restorative environment that helps alleviate pain, injury and health conditions, solving each individual need.‍

Exosome therapy

Applies to therapy

Regenerative therapy to address conditions such as chronic pain, osteoarthritis and musculoskeletal injuries.

Although stem cells are usually responsible for cellular rejuvenation, external factors can hinder their function [5]. Supporting their function with exosomes could enhance their effect [6], as they would provide the necessary information for the repair process. ‍

Regenerative Aesthetics

Applies to therapy

State-of-the-art skin and hair rejuvenation for a more youthful appearance.

Exosomes can play a key role in improving skin health and curbing hair loss. Their cell-to-cell communication helps stimulate, repair and rejuvenate by transporting their cargo of beneficial molecules directly to the skin or hair cells.‍

How does it work?

1

Eligibility

We start with an eligibility form. If you are eligible, we will continue with the intake process, which includes a review of your medical history and health status.

2

Regenerative therapy

A treating physician will work with you and our advisory board to design a customized therapeutic protocol that considers your needs and goals.

3

Follow-up

We will evaluate your results to offer you additional assistance. Additional sessions may be necessary, depending on your response to therapy.

Cenegenics: Scientific Wellness

Our regenerative approach

As we age, the quantity and potency of our stem cells decreases [2], while senescent cells (quiescent cells) grow [3], so we recover more slowly and are more susceptible to disease [4-9].
‍
Our therapeutic goal is to restore the quantity of stem cells (UC-MSCs) and other reparative molecules to improve cellular function, weakened due to acute damage, chronic disease or degeneration over time [10].

*This chart is for informational purposes only.

Boost your healing power

To create an optimal internal restorative environment, it can serve as an option or complement to drugs and surgical interventions, as well as a preventive and esthetic measure, solving each individual need*.

Minimally invasive*.

No scars*.

Without hospitalization

Promotes regeneration*

Regulates the immune system*.

Decreases inflammation*.

*This chart is for informational purposes only.

Benefits for all

Regenerative therapies have the potential to transform the quality of life of perfectly healthy people and people with health problems*.

Longevity and prevention*.

A new supply of stem cells and repair molecules can go a long way toward restoring health and maintaining homeostasis as we age*.

Aesthetic effects

Regenerative therapies stimulate the production of bioactive molecules, such as collagen, elastin and hyaluronic acid, key to reversing the most common signs of aging*.

Relief of pain and joint injuries*.

Regenerative therapies have proven to be very beneficial in healing joint injuries, sports injuries and trauma, relieving pain and regenerating tissue without scarring*.

Relief of health conditions*.

Clinical studies around the world have demonstrated the clinical benefits of regenerative therapies in various congenital, immune and chronic conditions, without adverse effects*.

Science-backed regenerative therapies in a clinical setting

COFEPRIS License

Our Cenegenics clinics in Mexico are licensed and authorized by COFEPRIS (the equivalent institution to the FDA in Mexico) to apply regenerative therapies for therapeutic purposes.

Validated protocols

Currently, the clinical use of stem cells or other expanded cells is not authorized in the United States. In Mexico there is the possibility of applying them for therapeutic purposes if all the required legal regulations are complied with.

Proven benefits

Therapy outcomes are quantified by measuring changes in single inflammatory markers, along with subjective data provided on follow-up forms.

Accredited products

Our cellular products are sourced from cGMP-compliant accredited laboratories, are ISO 9001 and ISO 13485 certified, and exceed FDA and ISCT standards.

Prestigious board

We collaborate with leading academic research centers, renowned investigators and review boards to confirm our meticulously designed therapeutic stem cell protocols.

Frequently Asked Questions

About

Regenerative therapies

What is regenerative therapy?

Regenerative therapies are purely biological therapies that use molecules naturally present in the body (e.g. mesenchymal stem cells) to stimulate the cell regeneration process. Their function is to repair damaged cells or tissues, protect existing cells, correct immune imbalances and reduce cellular inflammation.

What are regenerative therapies for?

Every repair that takes place in the body is driven by stem cells and their growth factors (e.g., exosomes). For this reason, regenerative therapies have an incredible range of applications.

At Cenegenics, we apply regenerative therapies with the goal of restoring cellular function, which may have been weakened due to acute damage, chronic disease, or degeneration over time [10]. Creating an optimal internal restorative environment can serve as an option or complement to drugs and surgical interventions, as well as a preventive and aesthetic measure, solving each need in a personalized manner.

Who are candidates for regenerative therapy?

Regenerative therapies have the potential to transform the quality of life for both perfectly healthy people and people with health problems, but they must be applied to the right conditions and the right people. If you think you or a loved one could benefit from regenerative therapy, fill out our online eligibility form.

What is stem cell therapy?

Stem cell therapy involves the clinical application of stem cells to treat or control various health conditions, injuries and diseases. This approach is part of the latest advances in medical research and has the potential to improve outcomes for patients with diseases for which there are currently limited treatment options.

Mesenchymal stem cells (UC-MSCs)

What are stem cells?

Stem cells are the raw material of the body, as they are the cells from which all other cells with specialized functions are created. Stem cells are undifferentiated cells that are activated when the body needs them for repair. Every repair that takes place in the body is directed by stem cells [1]. For this reason, stem cell therapies have an incredible range of applications [2].2].‍

What are mesenchymal stem cells?

Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal, differentiation, immunomodulation, anti-inflammation and signaling properties [3, 4]. These cells can be obtained from various tissues, such as adipose (fat) tissue, bone marrow, umbilical cord tissue, blood, liver, dental pulp, and skin [5, 6].‍

What is the source of the most promising mesenchymal stem cells?

To date, mesenchymal stem cells isolated and cultured from umbilical cord tissue (UC-MSCs) are considered a fundamental source for the culture of these cells [7]. Research is beginning to suggest that umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs) may be more potent than other sources of mesenchymal stem cells, which would increase their clinical efficacy [8]. ‍

What makes mesenchymal stem cells clinically useful?

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are widely used in the treatment of various diseases due to their self-renewal, differentiation, immunomodulation, anti-inflammation and signaling properties [3, 4, 9]. In vitro (performed in a laboratory) and in vivo (in a living organism) studies have contributed to the understanding of the mechanisms, safety and efficacy of UC-MSCs therapy in clinical applications [8]. ‍

Are mesenchymal stem cells safe?

Yes, UC-MSCs are safe and well tolerated [10]. Multiple peer-reviewed studies have demonstrated that the procedure is safe. Since 1995, stem cells have been used in multiple clinical studies. According to the U. S. National Library of Medicine (https://clinicaltrials.gov), as of 2020 there were 1240 registered clinical studies using mesenchymal stem cells [9] and there are currently more than 55,000 publications on MSCs [11]. All of the reviewed studies have demonstrated the safety of UC-MSCs [12].
‍
As with any medical procedure, for the therapy to be successful, certified cell products need to be applied with proper techniques. Candidates must also be screened to determine if they are appropriate candidates for therapy.‍

Is there any chance that my body will reject mesenchymal stem cells?

Mesenchymal stem cells are naturally present in the body [13] and are essentially new and immunoprivileged, so they are not usually subject to the same immune response as other foreign cells [7,14]. This makes them universally accepted and unable to be rejected. In addition, unlike other treatments, no blood products are used and no HLA matching is required.‍

What diseases can mesenchymal stem cells help?

Many diseases are related to an imbalance in the inflammatory or immune status. A regenerative therapy could significantly benefit patients [7]. UC-MSCs have demonstrated clinical efficacy in the following diseases:

Alzheimer's
Rheumatoid arthritis
COVID-19 (long-lasting/acute)‍
Diabetes (Type 1)‍
Reflex Sympathetic Dystrophy (RSD) or Reflex Sympathetic Dystrophy (RSD) or (CRPS)‍
ELA‍
COPD (or other degenerative/inflammatory lung diseases)‍
Crohn's disease
Lyme disease‍
Liver disease‍
Kidney disease‍
Autoimmune diseases‍
Neurological (degenerative) diseases‍
Multiple Sclerosis‍
Stroke (ischemic and hemiplegic)‍
Chronic inflammation‍
Heart failure/cardiomyopathy‍
Spinal cord injuries‍
Traumatic brain injury (TBI)‍
Lupus‍
Neuropathy‍
Parkinson‍

If you do not find your disease in the above list, please fill out our eligibility form. This will allow our medical team to evaluate your case.‍

Can stem cells help manage aging?

Stem cell depletion is one of the characteristic features of aging [15]. As we age, the number and potency of our stem cells decreases [16], while senescent cells (quiescent cells) increase [15]. As a result, we recover more slowly and are more susceptible to disease [17-21].
‍
UC-MSCs offer great potential to slow down the aging process. Their anti-inflammatory properties help reduce systemic inflammation, which is crucial to counteract age-related wear and tear.
This combination of reducing inflammation and promoting tissue repair helps to slow the aging process, improving overall health and longevity.‍

Are there ethical issues related to this stem cell therapy?

Although derived from the umbilical cord, UC-MSCs are adult stem cells. The use of adult mesenchymal stem cells does not raise the same ethical concerns as the use of fetal and embryonic stem cells. Both the Catholic Church [2] and the Southern Baptist Convention have issued statements supporting the research and use of adult stem cells in the treatment of human diseases, as they consider it an ethically acceptable alternative method to fetal and embryonic stem cells.‍

Mesenchymal stem cell-derived exosomes (UC-MSCs-Exos)

What are exosomes?

Exosomes are by-products of stem cells. They are extracellular vesicles (EVs) that contain, among other things, proteins (growth factors), mRNAs (the building blocks of proteins) and microRNAs (which activate or deactivate specific proteins) [1,2] that can be transferred to other cells to aid in repair and tissue homeostasis.

Extracellular vesicles (EVs) are vital to the functioning of the organism, as our cells communicate almost exclusively through them.

Does the source of the exosomes matter?

Yes, exosome loading varies significantly depending on the type and state of the progenitor cell [3]. In this case, the exosomes of UC-MSCs carry the developmental message of umbilical cord-derived mesenchymal stem cells, which are connective tissue progenitor cells, and thus participate in the development of tissues such as skin, hair, bone, muscle and cartilage [4].

What makes exosomes clinically useful?

Although stem cells are usually responsible for cellular rejuvenation, external factors may hinder their function [5]. Supporting their function with exosomes could enhance their effect [6], as they would provide the necessary information for the repair process.

In studies, exosomes improved wound healing, stimulated bone regeneration and enabled cartilage repair [7]. The next generation of regenerative therapy is based on isolating the therapeutic signals (exosomes) released by stem cells.

How can exosomes help?

Exosomes derived from UC-MSCs represent a promising cell-free therapy for tissue engineering, as they can influence tissue responses to injury, infection and disease [8]. So far, sufficient scientific evidence has been accumulated to support the therapeutic value of exosomes in various human diseases [9].

Detail

Protocol

What is our therapeutic approach?

Our therapeutic goal is to restore the quantity of stem cells (UC-MSCs) and other reparative molecules to improve cellular function, weakened due to acute damage, chronic disease or degeneration over time [10]. Existing research supports the ability of UC-MSCs to regenerate damaged tissues, reduce inflammation, and modulate immune responses. These functions can make a significant improvement to overall health, as they can alleviate symptoms and stabilize a disease, as well as improve quality of life.‍

What type of mesenchymal stem cells do we apply?

We use umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs) expanded in culture. Our cells are ethically sourced from full-term human umbilical cords, donated in the U.S. and certified by the AATB, and processed in our award-winning partner medical laboratory, also located in the U.S. and fully FDA-registered.

The laboratory is cGMP compliant and ISO 9001 and ISO 13485 certified. Cells are viability tested according to ISCT standards to ensure that they meet minimum quality control requirements several times prior to treatment.

To ensure cell safety, advanced testing for sterility, endotoxins, mycoplasma, HIV-1/HIV-2, hepatitis B and C, and syphilis is performed. URMC flow cytometry tests are also performed to confirm the identity of the cells after thawing and to verify the phenotype expression of UC-MSCs (CD73+, CD90+, CD105, etc.).‍

How many mesenchymal stem cells are administered?

All of our therapeutic protocols are customized based on the candidates' profile, health status and condition. Once you are eligible for therapy, the dose of umbilical cord tissue-derived mesenchymal stem cells will be established.‍

How are mesenchymal stem cells administered?

UC-MSCs are usually administered intravenously at a rate of approximately 1 cc per minute by a certified and experienced physician. The infusion takes two to three hours. This is a minimally invasive procedure that requires between one and two hours of recovery.‍

Is the procedure painful?

The procedure is noninvasive and there is no pain associated with the infusion of cells. Some mild discomfort may occur during the procedure, but it is minimal.‍

How do these regenerative therapies differ from those offered in the U.S.?

Currently, the clinical use of stem cells or other expanded cells is not authorized in the United States. Although there are many clinics in the United States that offer "stem cell therapies," these clinics operate without FDA clearance and are highly restricted in their scope, the number of cells they use, and their quality. Because of these U.S. laws, many people have traveled abroad for regenerative therapies, including many high-profile athletes and celebrities.
‍
In Mexico, there is the possibility of applying regenerative therapies for therapeutic purposes if all the required legal regulations are complied with. Regenerative therapies for therapeutic purposes are fully regulated in Mexico, which has given rise to a booming medical tourism industry in the last decade.‍

Can I use my own cells or those of a family member?

Our laboratory only uses AATB certified suppliers of U.S. donated umbilical cord tissue and does not accept cords from outside, as our laboratory is specifically calibrated to accept cords from these suppliers, with strict specifications. Accepting cords from outside sources would call quality control into question and would require the production process to be stopped within the lab to avoid cross contamination issues, although this could be done, it would involve much more time and money, with no biological benefit.

From a medical point of view, there is no difference between cord sources for isolated UC-MSCs. Umbilical cord tissue-derived mesenchymal stem cells are essentially unclaimed and immunoprivileged, so there is no noticeable benefit to using cells from a particular donor.‍

Are stem cells frozen?

To preserve cell viability (the number of live cells), mesenchymal stem cells are cryogenically preserved in a protective solution at -150°F just after expansion. Once ready for use, the cells are carefully transported at the appropriate temperature and immediately checked for cell count and viability to ensure that they meet all necessary quality assurance standards. If they do not meet optimal standards (viability numbers), they are not used.‍

Our clinic

Is your clinic licensed to apply regenerative therapies?

Yes, our clinic in Mexico City is licensed and authorized by COFEPRIS (the equivalent institution to the FDA in Mexico) to apply regenerative therapies for therapeutic purposes. We are one of the few medical centers in the world licensed to apply these therapies for therapeutic purposes.

Why do regenerative therapy in your clinic?

As we are licensed and authorized by the Mexican Government to apply regenerative therapies, you can be sure that the protocols, cellular products and medical personnel that apply the therapies are regulated and comply with all the required legal regulations.

Our regenerative protocols are reviewed and approved by a scientific and medical board with years of experience in regenerative medicine. We collaborate with established and certified laboratories that exceed current Good Manufacturing Practice (GMP), U.S. Food and Drug Administration (FDA) and International Society for Cellular Therapy (ISCT) regulations. All of our medical personnel are certified, registered and licensed.

As a U.S. company with operations in Mexico, our health regulations are extremely strict, similar to those in the U.S., the U.K. and the EU. We are committed to providing the highest quality standards to meet the regulatory and clinical aspects of the practice.

Do you have clinics in the United States?

Yes, we have clinics in major U.S. cities, but none of them offer regenerative therapies. Although our partner laboratory, which is FDA certified and fully cGMP compliant, is located in the United States, patients must be able to travel to our Mexico City clinic to participate in regenerative therapy.

Admission process

What information do you need before scheduling a therapy appointment?

All applicants must complete a panel of laboratory and other medical tests prior to final approval. The information provided will allow our medical team to establish a baseline of pre-infusion health status and ensure that the patient meets the eligibility criteria for therapy. These tests must be completed in order to be approved for therapy.
‍
Specific requirements will be detailed via email upon completion and acceptance of the intake form. Our team will be available to answer any questions you may have about the admissions process.

How long does the admission process take?

We have designed our admissions process to be as simple as possible. Once the online form is submitted, the process usually takes two to three weeks.

Is there anything that can exclude me from regenerative therapy?

The purpose of the eligibility form is to screen out applicants who are ineligible before starting the admission process. Once the process is initiated, various diagnostic tests will be requested to ensure that the applicant does not have any conditions that may affect eligibility.

Prices

What is the price of a regenerative therapy?

All of our therapies are customized to your needs. You will receive a quote once you have completed the intake process and your application has been approved.

What payment methods do you accept?

We accept payments by bank transfer, Visa, Mastercard, American Express and most debit cards.

What is your payment policy?

To schedule the procedure, full payment in advance is required. Once this and the dates are confirmed, the stem cells will be ordered from the laboratory and carefully scheduled to arrive on the day of the procedure. No refunds are offered in the event of a no-show for the regenerative therapy appointment.

What is your cancellation policy?

All deposits are fully refundable up to two weeks prior to the scheduled date. If you are unable to keep your appointment or need to reschedule, our team can help you arrange another date at no additional cost.

Does my insurance cover regenerative therapy?

Generally, neither pre-testing nor regenerative therapy is covered by insurance companies. We are working with the best insurance companies to offer Cenegenics' solutions to their customers.

Results

Results: Mesenchymal Stem Cells (UC-MSCs)

How soon will I see results?

Our patients have experienced measurable results within 3 to 6 months. This is indicated by marked reductions in inflammation levels and changes in their overall vitality, which are measured through our follow-up form. It is also common for patients to report improvements in their quality of life and a decrease in their symptoms in the first few weeks after infusion. However, each patient is unique and their response to therapy may vary.‍

Are there any side effects?

Multiple peer-reviewed studies have concluded that mesenchymal stem cells are a safe cell product. Common short-term side effects following mesenchymal stem cell infusion are fatigue, headache and nausea, which resolve quickly. All of our patients are under direct medical supervision throughout the entire process, both during therapy and the recovery period.

At Cenegenics Wellness we have never had patients report ill effects after therapy or a worsening of their condition, nor have we heard of any short-term side effects lasting more than two or three hours.‍

How long do the effects of mesenchymal stem cells last?

The response to therapy depends on a wide variety of biological factors and also on the patient's behavior and lifestyle. Patients who follow an active lifestyle, follow an anti-inflammatory diet and restrict alcohol, tobacco and caffeine intake may have sustained results for two years or more, depending on the disease. Most patients have reported little sign of regression for up to 24 months after infusion and rarely return to their original state.

It is important to keep in mind that each patient is different and responds to therapy differently. It is currently not possible to accurately predict the results of a stem cell infusion. We strongly encourage prospective patients to investigate before undergoing this therapy. This is a new but promising field for the treatment of many otherwise untreatable diseases.‍

How do we measure results?

To assess the results of therapy, we measured changes in single inflammatory markers along with subjective data provided on follow-up forms.‍

Will I need more than one session?

Before determining whether additional sessions are necessary, we evaluate the results of the therapy. Some patients decide to return voluntarily to achieve further improvements.‍

Why will the Cenegenics approach help me improve my response to regenerative therapy?

The most effective way to harness the power of stem cells in the body is to optimize overall health, and this is the core philosophy of Cenegenics. At Cenegenics, we don't just apply regenerative therapy and wait for the stem cells to do the work. Our goal is to maximize the function of your body's stem cells, correcting the factors that impair them and supporting them from a holistic approach that includes effective interventions such as proper nutrition, supplementation and more.

How to start?

Fill out the eligibility form

How do I start the admission process?

To participate in the therapy admission process, you will need to fill out an online eligibility form. This form will provide our medical team with the preliminary information needed to determine if you are eligible for our therapies.

The process consists of three steps that each applicant must follow before final approval:

Eligibility:

Fill out the online eligibility form.

Admission:

Follow the admission process.

Consultation:

Complete a consultation or video consultation.

Applies to regenerative therapy

Please fill out the eligibility form in the language of your choice. If you meet the requirements, we will begin the admission process.

English English

The medicine of the future in your hands

Cellular rejuvenation

Therapies to repair

Regenerative therapies

How does it work?

1

2

3

Our regenerative approach

Boost your healing power

Benefits for all

Science-backed regenerative therapies in a clinical setting

Frequently Asked Questions

Applies to regenerative therapy

Live better, now and in the future