We share studies that support the application of precision medicine-based solutions - comprehensive health programs, advanced diagnostics, regenerative cell therapies, and intravenous supplementation - under appropriate medical supervision so as not to generate or infer false expectations.
Performance Health Programs (PSR) icon.

Performance Health Programs (PSR)

Age Management
  1. Campanelli, Linda, C., Ph.D. "Theories of Aging." Theories and Psychosocial Aspects of Aging (1) 3-13.
  2. Rotstein, M. (Ed). Review of Biological Research in Aging, vol. 4. New York: Wiley-Liss, 1990.
  3. Capurso, A., Panza, F., Solfrizzi, V., Torres, F., Carpuso, C., Mastroianni, F., Del Parigi, A. "Age-related cognitive decline: Evaluation and prevention strategy." Recenti Prog Med 2009; 91: 127-34.
  4. Chan, K.M., Raja, A.J., Strohschein, F.J., Lechelt, K. "Age-related changes in muscle fatigue resistance in humans." Can J Neurol Sci 2000; 27: 220-8.
  5. Chauhan, J., Hawrysh, Z.J., Gee, M., Donald, E.A., Báu, T.K. "Age-related olfactory and taste changes and interrelationships between taste and nutrition." J Am Diet Assoc 1987: 87: 1543-50.
  6. Fleg, J.L. "Alterations in cardiovascular structure and function with advancing age." Am J Cardiologies 1986; 57: 33C-44C.
  7. Hayflick, L. How and Why We Age. New York: Ballantine Books, 1994; pp. 222-262.
  8. Piers, L.S., Soares, M.J., McCormack, L.M., O'Dea, K. "Is there evidence for an age-related reduction in metabolic rate?" J Appl Physiol 1998; 85: 2196-204.
  9. Sharma, Ramesh. "Theories of Aging," in Physiological Basis of Aging and Geriatrics. Florida: CRC Press, 1994; 37-44.
  10. Sonneborn, T. "The Origin, Evolution, Nature, and Causes of Aging," in Behnke, J., Since, C., and Moment, G. (Des), The Biology of Aging. New York: Plenum Press, 1979; p. 341.
  11. Van Cauter, E., Leproult, R., Plat, L. "Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men." JAMA 2000; 284: 861-8.

Precision nutrition
  1. O'Keefe JH, Gheewala NM, O'Keefe JO (2008) Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiologies 51: 249-255.
    Sesso HD, Paffenbarger Jr RS, Lee IM (2001) Alcohol consumption and risk os prostate cancer: The Harvard Alumni Health Study. Int J of Epi 30:749-755.

Metabolic and hormonal optimization
  1. Butler RN, Fossel M, Mitchell H, Heward CB, Olshansky SJ, Perls TT, Rothman DJ, Rothman SM, Warner HR, West MD, and Wright WF (2002) Is there an anti-aging medicine? J of Gerontology Series A: Bio Sci Med Sci (57):B333-B3385.
  2. Das UN (2006) Exercise and inflammation. The Euro Heart J. 27(11): 1385.

Nutritional supplementation
  1. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297 (8): 842-857.
  2. Willett WC, Stampfer MJ (2001) Clinical practice. What vitamins should I be taking, doctor? N Engl J Med 345 (25):1819-1824.
Advanced diagnostics icon.

Advanced diagnostics

Telomere measurement
  1. Atzmon, G., M. Cho, R. M. Cawthon, et al. "Evolution in Health and Medicine Sackler Colloquium: Genetic Variation in Human Telomerase Is Associated with Telomere Length in Ashkenazi Centenarians." Proceeding of the National Academy of Sciences (January 26, 2010): Suppl.1:1710-1717.
  2. Andrews, William. "Telomerase Activation: The Future of Anti-Aging Medicine." Presentation at the American Academy of Anti-Aging Conference, September 11, 2009.
  3. Babizhayev, M. A., E. L. Savel'yeva, S. N. Moskvina, et al. "Telomere Length Is a Biomarker of Cumulative Oxidative Stress, Biologic Age, and Independent Predictor of Survival and Therapeutic Treatment Requirements Associated with Smoking Behavior." American Journal of Therapeutics (March 29, 2010).
  4. Blackburn, Elizabeth. "Stress, Telomeres and Telomerase in Humans." University of California-San Francisco, Department of Biochemistry and Biophysics.
  5. Epel,E. S., E. H. Blackburn, J. Lin, et al. "Accelerated Telomere Shortening in Response to Life Stress." Proceedings of the National Academy of Sciences of the United States of America (September 28, 2004).
  6. Ocampo, C. "Telomere Talk: The Nutrition Connection." Journal of Nutrition for the Eldery 29, no. 1 (January 2010): 110-111.
Icon of regenerative therapies.

Regenerative cell therapies

Mesenchymal stem cell therapies
  1. A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy
  2. Al Demour S, Jafar H, Adwan S, AlSharif A, Alhawari H, Alrabadi A, Zayed A, Jaradat A, Awidi A. Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial. Urol Int. 2018;101(3):358-365. doi: 10.1159/000492120. Epub 2018 Aug 31. PMID: 30173210.
  3. Alipour M, Nabavi SM, Arab L, Vosough M, Pakdaman H, Ehsani E, Shahpasand K. Stem cell therapy in Alzheimer's disease: possible benefits and limiting drawbacks. Mol Biol Rep. 2019 Feb;46(1):1425-1446. doi: 10.1007/s11033-018-4499-7. Epub 2018 Dec 18. PMID: 30565076.
  4. Bahk JY, Jung JH, Han H, Min SK, Lee YS. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplantation: preliminary report of 7 cases. Exp Clin Transplant. 2010 Jun;8(2):150-60. PMID: 20565373.
  5. Barczewska M, Maksymowicz S, Zdolińska-Malinowska I, Siwek T, Grudniak M. Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study. Stem Cell Rev Rep. 2020 Oct;16(5):922-932. doi: 10.1007/s12015-020-10016-7. PMID: 32725316; PMCID: PMC7456414.
  6. Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L. Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis. Biologicals. 2013 Nov;41(6):439-45. doi: 10.1016/j.biologicals.2013.09.004. Epub 2013 Oct 14. PMID: 24135082.  
  7. Bradstreet JJ, Sych N, Antonucci N, Klunnik M, Ivankova O, Matyashchuk I, Demchuk M, Siniscalco D. Efficacy of fetal stem cell transplantation in autism spectrum disorders: an open-labeled pilot study. Cell Transplant. 2014;23 Suppl 1:S105-12. doi: 10.3727/096368914X684916. Epub 2014 Oct 9. PMID: 25302490.
  8. Brazzini A, Cantella R, De la Cruz A, Yupanqui J, León C, Jorquiera T, Brazzini M, Ortega M, Saenz LN. Intraarterial autologous implantation of adult stem cells for patients with Parkinson disease. J Vasc Interv Radiol. 2010 Apr;21(4):443-51. doi: 10.1016/j.jvir.2010.01.008. Erratum in: J Vasc Interv Radiol. 2010 Jul;21(7):1141. PMID: 20346882.
    Lige L, Zengmin T. Transplantation of Neural Precursor Cells in the Treatment of Parkinson Disease: An Efficacy and Safety Analysis. Turk Neurosurg. 2016;26(3):378-83. doi: 10.5137/1019-5149.JTN.10747-14.4. PMID: 27161464.
  9. Bydon M, Dietz AB, Goncalves S, Moinuddin FM, Alvi MA, Goyal A, Yolcu Y, Hunt CL, Garlanger KL, Del Fabro AS, Reeves RK, Terzic A, Windebank AJ, Qu W. CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury. Mayo Clin Proc. 2020 Feb;95(2):406-414. doi: 10.1016/j.mayocp.2019.10.008. Epub 2019 Nov 27. PMID: 31785831.
  10. Carstens MH, Gómez A, Cortés R, Turner E, Pérez C, Ocon M, Correa D. Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells. Stem Cell Res. 2017 Jan;18:14-21. doi: 10.1016/j.scr.2016.12.001. Epub 2016 Dec 8. PMID: 27984756.
  11. Centeno CJ, Schultz JR, Cheever M, Freeman M, Robinson B, et al. (2011) A Case Series of Percutaneous Treatment of Non-Union Fractures with Autologous, Culture Expanded, Bone MarrowDerived, Mesenchymal Stem Cells and Platelet Lysate. J Bioengineer & Biomedical Sci S2:007.doi:10.4172/2155-9538.S2-007
  12. Cheng H, Liu X, Hua R, Dai G, Wang X, Gao J, An Y. Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury. J Transl Med. 2014 Sep 12;12:253. doi: 10.1186/s12967-014-0253-7. PMID: 25209445; PMCID: PMC4172930.
  13. Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol. 2012 Feb;11(2):150-6. doi: 10.1016/S1474-4422(11)70305-2. Epub 2012 Jan 10. PMID: 22236384; PMCID: PMC3279697.
  14. Christopher D Riemann, Eyal Banin, Adiel Barak, David S Boyer, Rita Ehrlich, Tareq Jaouni, Richard McDonald, David Telander, Michael Keane, Jessica Ackert, Mark D. Ferguson, Avi Ben- Shabat, Jordi Mones, Diana Angelini, Gary S. Hogge, Benjamin Reubinoff; Phase I/IIa Clinical Trial of Human Embryonic Stem Cell (hESC)-Derived Retinal Pigmented Epithelium (RPE, OpRegen) Transplantation in Advanced Dry Form Age-Related Macular Degeneration (AMD): Interim Results. Invest. Ophthalmol. Vis. Sci. 2020;61(7):865.
  15. da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM, Gooljar SB, Carr AF, Vugler A, Ramsden CM, Bictash M, Fenster M, Steer J, Harbinson T, Wilbrey A, Tufail A, Feng G, Whitlock M, Robson AG, Holder GE, Sagoo MS, Loudon PT, Whiting P, Coffey PJ. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018 Apr;36(4):328-337. doi: 10.1038/nbt.4114. Epub 2018 Mar 19. PMID: 29553577.
  16. Dai G, Liu X, Zhang Z, Yang Z, Dai Y, Xu R. Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury. Brain Res. 2013 Oct 2;1533:73-9. doi: 10.1016/j.brainres.2013.08.016. Epub 2013 Aug 12. PMID: 23948102.
  17. Dawson G, Sun JM, Davlantis KS, Murias M, Franz L, Troy J, Simmons R, Sabatos-DeVito M, Durham R, Kurtzberg J. Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial. Stem Cells Transl Med. 2017 May;6(5):1332-1339. doi: 10.1002/sctm.16-0474. Epub 2017 Apr 5. PMID: 28378499; PMCID: PMC5442708.
  18. Desai P, Hasan SM, Zambrana L, Hegde V, Saleh A, Cohn MR, Lane JM. Bone Mesenchymal Stem Cellswith Growth Factors Successfully Treat Nonunions and Delayed Unions. HSS J. 2015 Jul;11(2):104-11.doi: 10.1007/s11420-015-9432-1. Epub 2015 Mar 25. PMID: 26140028; PMCID: PMC4481261.
  19. Dubsky M, Jirkovska A, Bem R, Fejfarova V, Pagacova L, Sixta B, Varga M, Langkramer S, Sykova E, Jude EB. Both autologous bone marrow mononuclear cell and peripheral blood blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment. Diabetes Metab Res Rev. 2013 Jul;29(5):369-76. doi: 10.1002/dmrr.2399. PMID: 23390092.  
  20. Forbes GM, Sturm MJ, Leong RW, Sparrow MP, Segarajasingam D, Cummins AG, Phillips M, Herrmann RP. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy. Clin Gastroenterol Hepatol. 2014 Jan;12(1):64-71. doi: 10.1016/j.cgh.2013.06.021. Epub 2013 Jul 19. PMID: 23872668.
  21. Garber MG and Carlos ND. Intracavernous administration of adipose stem cells: a new technique of treating erectile dysfunction in diabetic patient, preliminary report of 6 cases. MOJ Cell Sci Rep. 2015;2(1):5-8.
  22. Geffner LF, Santacruz P, Izurieta M, Flor L, Maldonado B, Auad AH, Montenegro X, Gonzalez R, Silva F. Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell Transplant. 2008;17(12):1277-93. doi: 10.3727/0963689090878787648074. PMID: 19364066.
  23. Ghoryani M, Shariati-Sarabi Z, Tavakkol-Afshari J, Ghasemi A, Poursamimi J, Mohammadi M. Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran. Biomed Pharmacother. 2019 Jan;109:1834-1840. doi: 10.1016/j.biopha.2018.11.056. epub 2018 Nov 26. PMID: 30551438.
  24. Golpanian S, DiFede DL, Khan A, et al. Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty. J Gerontol A Biol Sci Med Sci. 2017;72(11):1505-1512. doi:10.1093/gerona/glx056.
  25. Guillaume-Jugnot P, Daumas A, Magalon J, Jouve E, Nguyen PS, Truillet R, Mallet S, Casanova D,Giraudo L, Veran J, Dignat-George F, Sabatier F, Magalon G, Granel B. Autologous adipose-derivedstromal vascular fraction in patients with Scleroderma: 12-month follow-up. Rheumatology (Oxford).2016 Feb;55(2):301-6. doi: 10.1093/rheumatology/kev323. Epub 2015 Sep 8. PMID: 26350489.
  26. Gu F, Wang D, Zhang H, Feng X, Gilkeson GS, Shi S, Sun L. Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. Clin Rheumatol. 2014 Nov;33(11):1611-9. doi: 10.1007/s10067-014-2754-4. Epub 2014 Aug 14. PMID: 25119864.
  27. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, Gerstenblith G, DeMaria AN, Denktas AE, Gammon RS, Hermiller JB Jr, Reisman MA, Schaer GL, Sherman W. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009 Dec 8;54(24):2277-86. doi: 10.1016/j.jacc.2009.06.055. PMID: 19958962; PMCID: PMC3580848.
  28. Haahr MK, Jensen CH, Toyserkani NM, Andersen DC, Damkier P, Sørensen JA, Lund L, Sheikh SP. Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine. 2016 Jan 19;5:204-10. doi: 10.1016/j.ebiom.2016.01.024. PMID: 27077129; PMCID: PMC4816754.
  29. Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H, Chen Y, Zhao W, Jia Z, Yan S, Wang Y. Long term effectsof the implantation of Wharton's jelly-derived mesenchymal stem cells from the umbilical cord for newlyonset type 1 diabetes mellitus. Endocr J. 2013;60(3):347-57. doi: 10.1507/endocrj.ej12-0343. Epub 2012Nov 16. PMID: 23154532.
  30. Hu J, Zhao G, Zhang L, Qiao C, Di A, Gao H, Xu H. Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis. Exp Ther Med. 2016 Nov;12(5):2983-2989. doi: 10.3892/etm.2016.3724. Epub 2016 Sep 20. PMID: 27882104; PMCID: PMC5103734.
  31. Hur JW, Cho TH, Park DH, Lee JB, Park JY, Chung YG. Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. J Spinal Cord Med. 2016 Nov;39(6):655-664. doi: 10.1179/2045772315Y.0000000048. Epub 2015 Jul 24. PMID: 26208177; PMCID: PMC5137573.
  32. Jiang R, Han Z, Zhuo G, Qu X, Li X, Wang X, Shao Y, Yang S, Han ZC. Transplantation of placentaderived mesenchymal stem cells in type 2 diabetes: a pilot study. Front Med. 2011 Mar;5(1):94-100. doi:10.1007/s11684-011-0116-z. Epub 2011 Mar 17. PMID: 21681681.
  33. Karussis D, Karageorgiou C, Vaknin-Dembinsky A, Gowda-Kurkalli B, Gomori JM, Kassis I, Bulte JW, Petrou P, Ben-Hur T, Abramsky O, Slavin S. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol. 2010 Oct;67(10):1187-94. doi: 10.1001/archneurol.2010.248. PMID: 20937945; PMCID: PMC3036569.
  34. Kahraman NS, Oner A. Umbilical cord derived mesenchymal stem cell implantation in retinitis pigmentosa: a 6-month follow-up results of a phase 3 trial. Int J Ophthalmol. 2020;13(9):1423-1429. Published 2020 Sep 18. doi:10.18240/ijo.2020.09.14.
  35. Kim HY, Kim H, Oh KW, Oh SI, Koh SH, Baik W, Noh MY, Kim KS, Kim SH. Biological markers of mesenchymal stromal cells as predictors of response to autologous stem cell transplantation in patients with amyotrophic lateral sclerosis: an investigator-initiated trial and in vivo study. Stem Cells. 2014 Oct;32(10):2724-31. doi: 10.1002/stem.1770. PMID: 24966156.
  36. Lasala GP, Silva JA, Minguell JJ. Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product. J Thorac Cardiovasc Surg. 2012 Aug;144(2):377-82. doi: 10.1016/j.jtcvs.2011.08.053. Epub 2011 Nov 12. PMID: 22079876. 
  37. Le Thi Bich P, Nguyen Thi H, Dang Ngo Chau H, Phan Van T, Do Q, Dong Khac H, Le Van D, Nguyen Huy L, Mai Cong K, Ta Ba T, Do Minh T, Vu Bich N, Truong Chau N, Van Pham P. Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study. Stem Cell Res Ther. 2020 Feb 13;11(1):60. doi: 10.1186/s13287-020-1583-4. PMID: 32054512; PMCID: PMC702020576.
  38. Li A, Tao Y, Kong D, Zhang N, Wang Y, Wang Z, Wang Y, Wang Y, Wang J, Xiao J, Jiang Y, Liu X, Zheng C. Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis. Exp Ther Med. 2017 Aug;14(2):1538-1546. doi: 10.3892/etm.2017.4687. Epub 2017 Jun 27. PMID: 28781629; PMCID: PMC5526206.
  39. Li JF, Zhang DJ, Geng T, Chen L, Huang H, Yin HL, Zhang YZ, Lou JY, Cao B, Wang YL. The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosis. Cell Transplant. 2014;23 Suppl 1:S113-22. doi: 10.3727/096368914X685005. Epub 2014 Nov 5. PMID: 25385295.
  40. Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S, Hou Y, Zeng X, Gilkeson GS, Sun L. Allogeneic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010 Aug;69(8):1423-9. doi: 10.1136/ard.2009.123463. Erratum in: Ann Rheum Dis. 2011 Jan;70(1):237. PMID: 20650877.
  41. Liang J, Zhang H, Zhao C, Wang D, Ma X, Zhao S, Wang S, Niu L, Sun L. Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases. Int J Rheum Dis. 2017 Sep;20(9):1219-1226. doi: 10.1111/1756-185X.13015. Epub 2017 Feb 20. PMID: 28217916.
  42. Limoli PG, Limoli C, Vingolo EM, Franzone F, Nebbioso M. Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropathy. Stem Cell Res Ther. 2021 May 6;12(1):275. doi: 10.1186/s13287-021-02351-4. PMID: 33957957; PMCID: PMC8101217.
  43. Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, Kim BJ, Hu X. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J Transl Med. 2013 Aug 27;11:196. doi: 10.1186/1479-5876-11-196. PMID: 23978163; PMCID: PMC3765833.
  44. Mendonça MV, Larocca TF, de Freitas Souza BS, Villarreal CF, Silva LF, Matos AC, Novaes MA, Bahia CM, de Oliveira Melo Martinez AC, Kaneto CM, Furtado SB, Sampaio GP, Soares MB, dos Santos RR. Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury. Stem Cell Res Ther. 2014 Nov 17;5(6):126. doi: 10.1186/scrt516. PMID: 25406723; PMCID: PMC4445989.
  45. Miyagawa S, Domae K, Yoshikawa Y, Fukushima S, Nakamura T, Saito A, Sakata Y, Hamada S, Toda K, Pak K, Takeuchi M, Sawa Y. Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy. J Am Heart Assoc. 2017 Apr 5;6(4):e003918. doi: 10.1161/JAHA.116.003918. PMID: 28381469; PMCID: PMC5532985.
  46. Nassar W, El-Ansary M, Sabry D, Mostafa MA, Fayad T, Kotb E, Temraz M, Saad AN, Essa W, Adel H. Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases. Biomater Res. 2016 Aug 5;20:21. doi: 10.1186/s40824-016-0068-0. Erratum in: Biomater Res. 2017 Apr 6;21:3. PMID: 27499886; PMCID: PMC4974791.  
  47. Nguyen Thanh L, Nguyen HP, Ngo MD, Bui VA, Dam PTM, Bui HTP, Ngo DV, Tran KT, Dang TTT, Duong BD, Nguyen PAT, Forsyth N, Heke M. Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder. Stem Cells Transl Med. 2021 Jan;10(1):14-26. doi: 10.1002/sctm.20-0102. Epub 2020 Sep 9. PMID: 32902182; PMCID: PMC7780798.
  48. Oh KW, Noh MY, Kwon MS, Kim HY, Oh SI, Park J, Kim HJ, Ki CS, Kim SH. Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis. Ann Neurol. 2018 Sep;84(3):361-373. doi: 10.1002/ana.25302. Epub 2018 Aug 31. PMID: 30048006; PMCID: PMC6175096.
  49. Oner A, Gonen ZB, Sevim DG, Smim Kahraman N, Unlu M. Suprachoroidal Adipose Tissue-Derived Mesenchymal Stem Cell Implantation in Patients with Dry-Type Age-Related Macular Degeneration and Stargardt's Macular Dystrophy: 6-Month Follow-Up Results of a Phase 2 Study. Cell Reprogram. 2018 Dec;20(6):329-336. doi: 10.1089/cell.2018.0045. PMID: 31251672.
  50. Özmert E, Arslan U. Management of retinitis pigmentosa by Wharton's jelly derived mesenchymal stem cells: preliminary clinical results. Stem Cell Res Ther. 2020 Jan 13;11(1):25. doi: 10.1186/s13287-020-1549-6. PMID: 31931872; PMCID: PMC6958670.
  51. Prabhakar S, Marwaha N, Lal V, Sharma RR, Rajan R, Khandelwal N. Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study. Neurol India. 2012 Sep-Oct;60(5):465-9. doi: 10.4103/0028-3886.103185. PMID: 2313502.
  52. Petrou P, Gothelf Y, Argov Z, Gotkine M, Levy YS, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D. Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials. JAMA Neurol. 2016 Mar;73(3):337-44. doi: 10.1001/jamaneurol.2015.4321. PMID: 26751635.
  53. Petrou P, Kassis I, Levin N, Paul F, Backner Y, Benoliel T, Oertel FC, Scheel M, Hallimi M, Yaghmour N, Hur TB, Ginzberg A, Levy Y, Abramsky O, Karussis D. Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis. Brain. 2020 Dec 1;143(12):3574-3588. doi: 10.1093/brain/awaa333. PMID: 33253391.
  54. Protogerou V, Michalopoulos E, Mallis P, et al. Administration of Adipose Derived Mesenchymal Stem Cells and Platelet Lysate in Erectile Dysfunction: A Single Center Pilot Study. Bioengineering (Basel). 2019;6(1):21. Published 2019 Mar 5. doi:10.3390/bioengineering6010021.
  55. Protogerou V, Beshari SE, Michalopoulos E, Mallis P, Chrysikos D, Samolis AA, Stavropoulos-Giokas C, Troupis T. The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study-6 Months Results. Medicines (Basel). 2020 Mar 18;7(3):14. doi: 10.3390/medicines7030014. PMID: 32197323; PMCID: PMC7151592.
  56. Qin HL, Zhu XH, Zhang B, Zhou L, Wang WY. Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot. Exp Clin Endocrinol Diabetes. 2016 Sep;124(8):497-503. doi: 10.1055/s-0042-103684. Epub 2016 May 24. PMID: 27219884.
  57. Rahyussalim AJ, Saleh I, Kurniawati T, Lutfi APWY. Improvement of renal function after human umbilical cord mesenchymal stem cell treatment on chronic renal failure and thoracic spinal cord entrapment: a case report. J Med Case Rep. 2017 Nov 30;11(1):334. doi: 10.1186/s13256-017-1489-7. PMID: 29187247; PMCID: PMC5707902.
  58. Riordan NH, Morales I, Fernandez G, Allen N, Fearnot NE, Leckrone ME, Markovich DJ, Mansfield D, Avila D, Patel AN, Kesari S, Paz Rodriguez J. Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. J Transl Med. 2018 Mar 9;16(1):57. doi: 10.1186/s12967-018-1433-7. Erratum in: J Transl Med. 2021 May 10;19(1):197. PMID: 29523171; PMCID: PMC5845260.
  59. Riordan NH, Hincapié ML, Morales I, Fernández G, Allen N, Leu C, Madrigal M, Paz Rodríguez J, Novarro N. Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels. Stem Cells Transl Med. 2019 Oct;8(10):1008-1016. doi: 10.1002/sctm.19-0010. Epub 2019 Jun 11. PMID: 31187597; PMCID: PMC6766688.
  60. Rushkevich YN, Kosmacheva SM, Zabrodets GV, Ignatenko SI, Goncharova NV, Severin IN, Likhachev SA, Potapnev MP. The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus. Bull Exp Biol Med. 2015 Aug;159(4):576-81. doi: 10.1007/s10517-015-3017-3. Epub 2015 Sep 22. PMID: 26395626.
  61. Ryu CM, Yu HY, Lee HY, Shin JH, Lee S, Ju H, Paulson B, Lee S, Kim S, Lim J, Heo J, Hong KS, Chung HM, Kim JK, Shin DM, Choo MS. Longitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of interstitialcystitis/bladder pain syndrome. Theranostics. 2018 Nov 9;8(20):5610-5624. doi: 10.7150/thno.27559.PMID: 30555567; PMCID: PMC6276303.
  62. Seffer I, Nemeth Z. Recovery from Bell Palsy after Transplantation of Peripheral Blood Mononuclear Cells and Platelet-Rich Plasma. Plast Reconstr Surg Glob Open. 2017 Jun 29;5(6):e1376. doi: 10.1097/GOX.0000000000001376. PMID: 28740784; PMCID: PMC5505845.
  63. Shadmanfar S, Labibzadeh N, Emadedin M, Jaroughi N, Azimian V, Mardpour S, Kakroodi FA, Bolurieh T, Hosseini SE, Chehrazi M, Niknejadi M, Baharvand H, Gharibdoost F, Aghdami N. Intra-articular knee implantation of autologous bone marrow-derived mesenchymal stromal cells in rheumatoid arthritis patients with knee involvement: results of a randomized, triple-blind, placebo-controlled phase 1/2 clinical trial. Cytotherapy. 2018 Apr;20(4):499-506. doi: 10.1016/j.jcyt.2017.12.009. Epub 2018 Feb 7. PMID: 29428486.
  64. Sharma A, Gokulchandran N, Sane H, Nagrajan A, Paranjape A, Kulkarni P, Shetty A, Mishra P, Kali M, Biju H, Badhe P. Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study. Stem Cells Int. 2013;2013:623875. doi: 10.1155/2013/623875. Epub 2013 Aug 25. PMID: 24062774; PMCID: PMC3767048.
  65. Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet. 2015 Feb 7;385(9967):509-16. doi: 10.1016/S0140-6736(14)61376-3. Epub 2014 Oct 15. PMID: 25458728.
  66. Singer W, Dietz AB, Zeller AD, Gehrking TL, Schmelzer JD, Schmeichel AM, Gehrking JA, Suarez MD, Sletten DM, Minota Pacheco KV, Coon EA, Sandroni P, Benarroch EE, Fealey RD, Matsumoto JY, Bower JH, Hassan A, McKeon A, Windebank AJ, Mandrekar JN, Low PA. Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy. Neurology. 2019 Jul 2;93(1):e77-e87. doi: 10.1212/WNL.0000000000007720. Epub 2019 May 31. PMID: 31152011; PMCID: PMC6659003.
  67. Song M, Lim J, Yu HY, Park J, Chun JY, Jeong J, Heo J, Kang H, Kim Y, Cho YM, Kim SW, Oh W, ChoiSJ, Jang SW, Park S, Shin DM, Choo MS. Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitisby Activating Wnt Signaling Pathway. Stem Cells Dev. 2015 Jul 15;24(14):1648-57. doi:10.1089/scd.2014.0459. Epub 2015 Apr 9. PMID: 25745847; PMCID: PMC4499842.
  68. Song WK, Park KM, Kim HJ, Lee JH, Choi J, Chong SY, Shim SH, Del Priore LV, Lanza R. Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients. Stem Cell Reports. 2015 May 12;4(5):860-72. doi: 10.1016/j.stemcr.2015.04.005. Epub 2015 Apr 30. PMID: 25937371; PMCID: PMC4437471.
  69. Stolk J, Broekman W, Mauad T, Zwaginga JJ, Roelofs H, Fibbe WE, Oostendorp J, Bajema I, Versteegh MI, Taube C, Hiemstra PS. A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema. QJM. 2016 May;109(5):331-6. doi: 10.1093/qjmed/hcw001. Epub 2016 Jan 27. PMID: 26819296; PMCID: PMC4888332.
  70. Sung Y, Lee SM, Park M, Choi HJ, Kang S, Choi BI, Lew H. Treatment of traumatic optic neuropathy using human placenta-derived mesenchymal stem cells in Asian patients. Regen Med. 2020 Oct;15(10):2163-2179. doi: 10.2217/rme-2020-0044. Epub 2020 Dec 14. PMID: 33315474.
  71. Takagi S, Mandai M, Gocho K, Hirami Y, Yamamoto M, Fujihara M, Sugita S, Kurimoto Y, Takahashi M. Evaluation of Transplanted Autologous Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in Exudative Age-Related Macular Degeneration. Ophthalmol Retina. 2019 Oct;3(10):850-859. doi: 10.1016/j.oret.2019.04.021. Epub 2019 Apr 26. PMID: 31248784.
  72. Tian C, Wang X, Wang X, Wang L, Wang X, Wu S, Wan Z. Autologous bone marrow mesenchymal stem cell therapy in the subacute stage of traumatic brain injury by lumbar puncture. Exp Clin Transplant. 2013 Apr;11(2):176-81. doi: 10.6002/ect.2012.0053. Epub 2012 Aug 11. PMID: 22891928.
  73. Tompkins BA, DiFede DL, Khan A, Landin AM, Schulman IH, Pujol MV, Heldman AW, Miki R, Goldschmidt-Clermont PJ, Goldstein BJ, Mushtaq M, Levis-Dusseau S, Byrnes JJ, Lowery M, Natsumeda M, Delgado C, Saltzman R, Vidro-Casiano M, Da Fonseca M, Golpanian S, Premer C, Medina A, Valasaki K, Florea V, Anderson E, El-Khorazaty J, Mendizabal A, Green G, Oliva AA, Hare JM. Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1513-1522. doi: 10.1093/gerona/glx137. PMID: 28977399; PMCID: PMC5861900.
  74. Umbilical Cord Blood Therapy Potentiated with Erythropoietin for Children with Cerebral Palsy: A Double-blind, Randomized, Placebo-Controlled Trial.
  75. Vaquero J, Zurita M, Rico MA, Bonilla C, Aguayo C, Fernández C, Tapiador N, Sevilla M, Morejón C, Montilla J, Martínez F, Marín E, Bustamante S, Vázquez D, Carballido J, Rodríguez A, Martínez P, García C, Ovejero M, Fernández MV; Neurological Cell Therapy Group. Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury. Cytotherapy. 2017 Mar;19(3):349-359. doi: 10.1016/j.jcyt.2016.12.002. Epub 2017 Jan 6. PMID: 28089079.
  76. Vasic V, Barth K, Schmidt MHH. Neurodegeneration and Neuro-Regeneration-Alzheimer's Disease and Stem Cell Therapy. Int J Mol Sci. 2019 Aug 31;20(17):4272. doi: 10.3390/ijms20174272. PMID: 31480448; PMCID: PMC6747457.
  77. Venkataramana NK, Kumar SK, Balaraju S, Radhakrishnan RC, Bansal A, Dixit A, Rao DK, Das M, Jan M, Gupta PK, Totey SM. Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease. Transl Res. 2010 Feb;155(2):62-70. doi: 10.1016/j.trsl.2009.07.006. Epub 2009 Aug 6. PMID: 20129486.
  78. Wang Z, Luo Y, Chen L, Liang W. Safety of neural stem cell transplantation in patients with severe traumatic brain injury. Exp Ther Med. 2017 Jun;13(6):3613-3618. doi: 10.3892/etm.2017.4423. Epub 2017 May 4. PMID: 28588689; PMCID: PMC5450816.
  79. Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y. Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study. Drug Des Devel Ther. 2019 Dec 19;13:4331-4340. doi: 10.2147/DDDT.S225613. PMID: 31908418; PMCID: PMC6930836.
  80. Wang D, Li J, Zhang Y, Zhang M, Chen J, Li X, Hu X, Hu X, Jiang S, Shi S, Sun L. Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther. 2014 Mar 25;16(2):R79. doi: 10.1186/ar4520. PMID: 24661633; PMCID: PMC4060570.
  81. Wang D, Zhang H, Liang J, Li X, Feng X, Wang H, Hua B, Liu B, Lu L, Gilkeson GS, Silver RM, Chen W, Shi S, Sun L. Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant. 2013;22(12):2267-77. doi: 10.3727/096368911X582769c. PMID: 24388428.
  82. Wiacek MP, Gosławski W, Grabowicz A, Sobuś A, Kawa MP, Baumert B, Paczkowska E, Milczarek S, Osękowska B, Safranow K, Zawiślak A, Lubiński W, Machaliński B, Machalińska A. Long-Term Effects of Adjuvant Intravitreal Treatment with Autologous Bone Marrow-Derived Lineage-Negative Cells in Retinitis Pigmentosa. Stem Cells Int. 2021 Jun 2;2021:6631921. doi: 10.1155/2021/6631921. PMID: 34122558; PMCID: PMC8192192.
  83. Xu J, Ji BX, Su L, Dong HQ, Sun WL, Wan SG, Liu YO, Zhang P, Liu CY. Clinical outcome of autologous peripheral blood stem cell transplantation in opticospinal and conventional forms of secondary progressive multiple sclerosis in a Chinese population. Ann Hematol. 2011 Mar;90(3):343-8. doi: 10.1007/s00277-010-1071-5. Epub 2010 Sep 25. PMID: 20872003.
  84. Zhang J, Lv S, Liu X, Song B, Shi L. Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial. Gut Liver. 2018 Jan 15;12(1):73-78. doi: 10.5009/gnl17035. PMID: 28873511; PMCID: PMC5753687.
  85. Zhang X, Liu J, Yu B, Ma F, Ren X, Li X. Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes. Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2041-2052. doi: 10.1007/s00417-018-4097-3. Epub 2018 Aug 30. PMID: 30167916.

IV Drips icon.

Intravenous Supplementation (IV Drips)

  1. Anah CO, Jarike LN, Baig HA. High dose ascorbic acid in Nigerian asthmatics. Trop Geogr Med 1980;32:132-137.23.
  2. Ashkenazy Y, Moshonov S, Fischer G, et al. Magnesium-deficient diet aggravates anaphylactic shock and promotes cardiac myolysis in guinea pigs. Magnes Trace Elem 1990;9:283-288.
  3. Bekier E, Wyczolkowska J, Szyc H, Maslinski C. The inhibitory effect of nicotinamide on asthma-like symptoms and eosinophilia in guinea pigs, anaphylactic mast cell degranulation in mice, and histamine release from ratisolated peritoneal mast cells by compound 48-80. Int Arch Allergy Appl Immunol 1974;47:737-748.27.
  4. Blanchard J, Tozer TN, Rowland M. Pharmacokinetic perspectives on megadoses of ascorbic acid. Am J Clin Nutr 1997;66:1165-1171.
  5. Bloch H, Silverman R, Mancherje N, et al. Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma. Chest 1995;107:1576-1581.
  6. Booth BE, Johanson A. Hypomagnesemia due to renal tubular defect in reabsorption of magnesium. J Pediatr 1974;85:350-354.
  7. Browne SE. Intravenous magnesium sulphate in arterial disease. Practitioner 1969;202:562-564.
  8. Browne SE. Magnesium sulphate in arterial disease. Practitioner 1984;228:1165-1166.42.
  9. Brunner EH, Delabroise AM, Haddad ZH. Effect of parenteral magnesium on pulmonary function, plasma cAMP, and histamine in bronchial asthma. J Asthma 1985;22:3-11.
  10. Caddell JL. Magnesium deprivation in sudden unexpected infant death. Lancet 1972;2:258-262.
  11. Chava B. Pocernich, D. Allan Butterfield, Elevation of glutathione as a therapeutic strategy in Alzheimer disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,Volume 1822, Issue 5, 2012, Pages 625-630, ISSN 0925-4439.
  12. Clague JE, Edwards RH, Jackson MJ. Intravenous magnesium loading in chronic fatigue syndrome. Lancet 1992;340:124-125.35.
  13. Ciarallo L, Brousseau D, Reinert S. Higherdose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med 2000;154:979-983.
  14. Ciarallo L, Sauer AH, Shannon MW. Intravenous magnesium therapy for moderate to severe pediatric asthma: results of a randomized, placebo-controlled trial. J Pediatr 1996;129:809-814.
  15. Cohen L, Kitzes R. Magnesium sulfate in the treatment of variant angina. Magnesium 1984;3:46-49.43.
  16. Collipp PJ, Goldzier S 3rd, Weiss N, et al. Pyridoxine treatment of childhood bronchial asthma. Ann Allergy 1975;35:93-97.25.Crocket JA. Cyanocobalamin in asthma. Acta Allergologica 1957;11:261-268.26.
  17. Cook CC, Thomson AD. B-complex vitamins in the prophylaxis and treatment of Wernicke-Korsakoff syndrome. Br J Hosp Med 1997;57:461-465.54.
  18. Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991;337:757-760.33.
  19. Demirkaya S, Vural O, Dora B, Topcuoglu MA. Efficacy of intravenous magnesium sulfate in the treatment of acute migraine attacks. Headache 2001;41:171-177.30.
  20. Durlach J, Bara M, Theophanides T. A hint on pharmacological and toxicological differences between magnesium chloride and magnesium sulphate, or of scallops and men. Magnes Res 1996;9:217-219.51
  21. Dyckner T, Wester PO. Ventricular extrasystoles and intracellular electrolytes before and after potassium and magnesium infusions in patients on diuretic treatment. Am Heart J 1979;97:12-18.52.
  22. Disashi T, Iwaoka T, Inoue J, et al. Magnesium metabolism in hyperthyroidism. Endocr J 1996;43:397-402.44.
  23. Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness. Br J Nutr 1973;30:277-283.36.
  24. Frustaci A, Caldarulo M, Schiavoni G, et al. Myocardial magnesium content, histology, and antiarrhythmic response to magnesium infusion. Lancet 1987;2:1019.
  25. Glass GB, Skeggs HR, Lee DH, et al. Applicability of hydroxocobalamin as a long-acting vitamin B12. Nature 1961;189:138-140.49.
  26. Green SM, Rothrock SG. Intravenous magnesium for acute asthma: failure to decrease emergency treatment duration or need for hospitalization. Ann Emerg Med 1992;21:260-265.
  27. Harakeh S, Jariwalla RJ, Pauling L. Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells. Proc Natl Acad Sci U S A 1990;87:7245-7249.
  28. Herbert V. Vitamin B12. Am J Clin Nutr 1981;34:971-972.50.
  29. Henrotte JG. The variability of human red blood cell magnesium level according to HLA groups. Tissue Antigens 1980;15:419-430.
  30. Howard JM, Davies S, Hunnisett A. Magnesium and chronic fatigue syndrome. Lancet 1992;340:426.34.
  31. Itokawa Y, Tanaka C, Kimura M. Effect of thiamine on serotonin levels in magnesium deficient animals. Metabolism 1972;21:375-379.55.
  32. Iseri LT, French JH. Magnesium: nature's physiologic calcium blocker. Am Heart J 1984;108:188-193.
  33. Lapp CW, Cheney PR. The rationale for using high-dose cobalamin (vitamin B12). CFIDS Chronicle Physicians' Forum 1993 (Fall):19-20.37.
  34. Malkiel-Shapiro B. Further observations on parenteral magnesium sulfate therapy in coronary heart disease: a clinical appraisal. S Afr Med J 1958;32:1211-1215.
  35. Malkiel-Shapiro B, Bersohn I, Terner PE. Parenteral magnesium sulphate therapy in coronary heart disease. A preliminary report on its clinical and laboratory aspects. Med Proc 1956;2:455-462.41.Neguib MA. Effect of magnesium on the thyroid. Lancet 1963;1:1405.45.
  36. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulphate relieves migraine attacks in patients with low serum ionized magnesium levels: a pilot study. Clin Sci 1995;89:633-636.29.
  37. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulfate relieves cluster headaches in patients with low serum ionized magnesium levels. Headache 1995;35:597-600.31.
  38. Manuel and Keenoy B, Moorkens G, Vertommen J, et al. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr2000;19:374-382.32.Moorkens G, Manuel and Keenoy B, Vertommen J, et al. Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue. Magnes Res 1997;10:329-337.39.
  39. Okayama H, Aikawa T, Okayama M, et al. Bronchodilating effect of intravenous magnesium sulfate in bronchial asthma. JAMA 1987;257:1076-1078.
  40. Pottenger FM. A discussion of the etiology of asthma in its relationship to the various systems composing the pulmonary neurocellular mechanism with the physiological basis for the employment of calcium in its treatment.Am J Med Sci 1924;167:203-249.21.
  41. Reed JC. Magnesium therapy in musculoskeletal pain syndromes - retrospective review of clinical results. Magnes Trace Elem 1990;9:330.38.
  42. Reynolds RD, Natta CL. Depressed plasma pyridoxal phosphate concentrations in adult asthmatics. Am J Clin Nutr 1985;41:684-688.24.
  43. Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous magnesium sulfate treatment for acute asthma in the emergency department: a systematic review of the literature. Ann Emerg Med 2000;36:181-190.
  44. Rosenbaum EE, Portis S, Soskin S. The relief of muscular weakness by pyridoxine hydrochloride. J Lab Clin Med 1941;27:763-770.46.
  45. Shealy CN, Cady RK, Veehoff D, et al. Magnesium deficiency in depression and chronic pain. Magnes Trace Elem 1990;9:333.40.
  46. Skobeloff EM, Spivey WH, McNamara RM, Greenspon L. Intravenous magnesium sulfate for the treatment of acute asthma in the emergency department. JAMA 1989;262:1210-1213.
  47. Stephen JM, Grant R, Yeh CS. Anaphylaxis from administration of intravenous thiamine. Am J Emerg Med 1992;10:61-63.53.
  48. Sure B, Easterling L. The protective action of vitamin B12 against the toxicity of dl-thyroxine. J Nutr 1950;42:221-225.47.
  49. Sydow M, Crozier TA, Zielmann S, et al. High-dose intravenous magnesium sulfate in the management of life-threatening status asthmaticus. Intensive Care Med 1993;19:467-471.
  50. Tiffany BR, Berk WA, Todd IK, White SR. Magnesium bolus or infusion fails to improve expiratory flow in acute asthma exacerbations. Chest 1993;104:831-834.
  51. Tuft L, Gregory J, Gregory DC. The effect of calcium pantothenate on induced whealing and on seasonal rhinitis. Ann Allergy 1958;16:639-655.28.
  52. Uchida K, Mitsui M, Kawakishi S. Monooxygenation of N-acetylhistamine mediated by L-ascorbate. Biochim Biophys Acta 1989;991:377-379.
  53. Undritz E. The therapy of anaphylactic conditions with large amounts of calcium. J Allergy 1937;8:625.22.
  54. Watts AB, Ross OB, Whitehair CK, MacVicar R. Response of castrated male and female hyperthyroid rats to vitamin B12. Proc Soc Exp Biol Med 1951;77:624-626.48.

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